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日本九州大学 清水邦义教授

2016-11-15 10:34:00    来源:仙芝楼    浏览:536次
  日本九州大学农学研究院环境农学部,博士,男,天然产物化学家,2000年毕业于九州大学农学系。随后于日本山口大学和九州大学做博士后(2000-2002)。2002年,他回到九州大学农学系任助理教授。2014年,他获得副教授职位。

  他主要致力于植物和菌类中天然产物的开发,获得了2006年和2014年的日本木材研究学会进步奖。目前他已经发表了超过150篇论文。2016国际灵芝大会发表《Triterpenoids: Clue for Understanding Multi-Medicinal effects of Ganoderma mushroom》从同一个灵芝乙醇萃取物观察到多种不同的活性与功效。





主要报告:


1. I. Kubo, T. J. Ha, K. Shimizu, Molecular Design of Soybean Lipoxygenase Inhibitors Based on Natural Products, A Comprehensive Survey of International Soybean Research - Genetics, Physiology, Agronomy and Nitrogen Relationships, James E. Board (Ed.), ISBN: 978-953-51-0876-4, InTech, DOI: 10.5772/52703., 2013.01.
2. I. Kubo, K. Shimizu, K. Fujita, Naturally Occurring Antifungal Agents and Their Modes of Action., In : Fungicides Volume I; D. Dhanasekaran, N. Thajuddin, A. Panneerselvam, Ed., InTech - Open Access Publisher, 2012.02.
3. I. Kubo, K. Shimizu, K. Nihei, MANICOBA, A quercetin rich Amazonian dish, In: Quercetin: Dietary Sources, Functions and Health Benefits- Nova Science Publishers, Inc., 2012.02.
4. I. Kubo, K. Fujita, K. Shimizu, Anti-Salmonella Agents from Tanacetum Balsamita, A Brazilian Medicinal Plant, and their Application, In: Antioxidants and Biocides from Latin American Plants; C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., CABI Publishing (UK), 2012.02.
5. N. Masuoka, K. Shimizu, I. Kubo, Antioxidant Activity of Anacardic Acids
, In: Antioxidants and Biocides from Latin American Plants; C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., CABI Publishing (UK)(2012), In: Antioxidants and Biocides from Latin American Plants;
C.L. Cespedes, D.A. Sampietro, D.S. Seigler, Ed., CABI Publishing (UK)(2012), 2012.02.
6. I. Kubo, N. Masuoka, T. J. Ha, K. Shimizu, K. Nihei, Multifunctional Antioxidant Activities of Alkyl Gallates, The Open Bioactive Compounds Journal, 3, 1-11(2010), 2010.06.
7. I. Kubo, T. J. Ha, T. Nitoda, K. Shimizu, A. Kubo, Multifunctional Acne Control Agents , Current Topics in Phytochemistry, 9, 95-102 (2008) , 2008.06.
8. K. Shimizu, Tyrosinase and 5a-Reductase Inhibitory Components from Artocarpus incisus, Bull. Kyushu Univ. For., 82, p21-63, 2001.01.
9. K. Shimizu, R. Kondo, K. Sakai, Tyrosinase inhibitors from Artocarpus incisus., Research Advances in Phytochemistry, 1, p19-34, 2000.01.



主要论文:


1.     Q. Zhu, T. H. Bang, K. Ohnuki, T. Sawai, K. Sawai, Shimizu K, Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design, Scientific Reports, 13194, 2015.06.
2.     T. Kohno, T. Hai-Bang, Q. Zhu, S. Sakamoto, H. Tanaka, S. Morimoto, Shimizu K, Tubulin polymerization stimulating-activity of Ganoderma triterpenoids(in press), in press, 2016.05.
3.     Yhiya M. Amen, Amira Mira, Hai-Bang Tran, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Shimizu K, Lucidumol C, a new lanostanoid triterpene from Ganoderma lingzhi with potential activity against colon cancer (in press), Journal of Natural Medicines, 2016.05.
4.     Yhiya M. Amen, Satoru Kaifuchi, Shimizu K, Methoxyflavones from Ganoderma lingzhi (in press)
, International Journal of Medicinal Mushrooms, 2016.05.
5.     Sakamoto, S, Kohno, T, Shimizu K, Tanaka, H, Morimoto, S., Detection of ganoderic acid A in Ganoderma lingzhi by an indirect competitive enzyme-linked immunosorbent assay, Planta Med, 2015.11.
6.     S. Tamrakar, H. B. Tran, M. Nishida, S. Kaifuchi, H. Suhara, K. Doi, K. Fukami, G. P. Parajuli, Shimizu K, Anti-oxidative Activities of 62 Wild Mushrooms from Nepal and the Phenolic Profile of Some Selected Species, Journal of Natural Medicines, 2016.06.
7.     Bang, T.H., Yamamoto, A., Matsumoto, S., Ito, H., Igami, K., Miyazaki, T., Kondo, R., Shimizu, K., Hypotensive effects of Reishi (Ganoderma lingzhi)’s auto-digested extract and its potent peptides for Angiotensin-Converting Enzyme inhibition, Molecules, 19, 2014.08.
8.     S. Fatmawati, RYUICHIRO KONDO, Shimizu K, Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as α-glucosidase inhibitors, 23, 21, 2013.11.
9.     S. Fatmawati, R. Kondo, K. Shimizu, Structure-activity relationships of lanostane-type triterpenoids from Ganoderma lingzhi as α-glucosidase inhibitors., Bioorg Med Chem Lett., 23, 21, 2013.11.
10.     T. H. Bang, A. Yamamoto, S. Matsumoto, H. Ito, K. Igami, T. Miyazaki, R. Kondo, K. Shimizu, Hypotensive effects of Reishi (Ganoderma lingzhi)’s auto-digested extract and its potent peptides for Angiotensin-Converting Enzyme inhibition., submitted, 2013.09.
11.     J. Liu, K.i Kurashiki, A. Fukuta, S.i Kaneko, Y. Suimi, K. Shimizu, R. Kondo, Quantitative determination of the representative triterpenoids in the extracts of Ganoderma lucidum with different growth stages using high-performance liquid chromatography for evaluation of their 5α-reductase inhibitory properties, Food Chemistry, 133, 1034-1038, 2012.02.
12.     S. Fatmawati, K. Shimizu, R. Kondo, Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors, Bioorganic & Medicinal Chemistry Letters, 21(24), 7295-7297, 2011.12.
13.     T.X. Meng, S. Furuta, S. Fukamizu, R. Yamamoto, H. Ishikawa, E.T. Arung, K. Shimizu, S. Ohga, R. Kondo, Evaluation of biological activities of extracts from the fruiting body of Pleurotus citrinopileatus for skin cosmetics, Journal of Wood Science, 57, 5, 2011.05.
14.     S. Fatmawati, K. Shimizu, R. Kondo , Ganoderol B: a potent alpha-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum, Phytomedicine, 18, 12, 2011.02.
15.     S. Fatmawati, K. Shimizu, R. Kondo, Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum, Planta Med, 76, 15, 2010.11.
16.     S. Fatmawati, K. Shimizu, R. Kondo, Ganoderic acid Df, a new triterpenoid with aldose reductase activity from the fruiting body of Ganoderma lucidum , Fitoterapia., 81, 8, 2010.09.
17.     J. Liu, K. Shimizu, R. Kondo, The effects of ganoderma alcohols isolated from Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells, Fitoterapia., 81, 8, 2010.09.
18.     J. Liu, J. Shiono, K. Shimizu, R. Kondo, Ganoderic acids from Ganoderma lucidum. Inhibitory activity of osteoclastic differentiation and structural criteria, Planta Med., 76, 137-139, 2010.05.
19.     K. Shimizu, I. Miyamoto, J. Liu, F. Konishi, S. Kumamoto, R. Kondo, Estrogen-like activity of ethanol extract of Ganoderma lucidum, J. Wood Sci., 55, 53-39 , 2009.04.
20.     J. Liu, S. Tamura, K. Kurashiki, K. Shimizu, K. Noda, F. Konishi, S. Kumamoto, R. Kondo, Anti-androgen effects of extracts and compounds from Ganoderma lucidum, Chem. Biodiversity, 6, 231-243, 2009.04.
21.     I. Miyamoto, J. Liu, K. Shimizu, A. Kukita, T. Kukita, M. Sato, R. Kondo, Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum, Eur. J. Pharmacol., 602, 1, 1-7, 2009.04.
22.     S. Fatmawatia, K. Kurashiki, S. Takeno, Y. Kim, K. Shimizu, M. Sato, K. Imaizumi, K. Takahashi, S. Kamiya, S. Kaneko, R. Kondo , The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum , Phytotherapy Research, 23, 28-32, 2009.03.
23.     M. Noguchi, K. Tomiyasu, M, Nakiri, K. Matsuoka, T. Kakuma, F. Konishi, S. Kumamoto, K. Shimizu, R. Kondo, An extract of ganoderma lucidum in men with lower urinary tract symptoms: A double-blind, placebo-controlled randomized and dose-ranging study, Nishinihon Journal of Urology, 70, 9, 466-472, 2008.04.
24.     M. Noguchi, T. Kakuma, K. Tomiyasu, Y. Kurita, H. Kukihara, F. Konishi, S. Kumamoto, K. Shimizu, R. Kondo, K. Matsuoka , The effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: A double-blaind, placebo-controlled randomized and dose-ranging study, Asian Journal of Andrology, 10, 4, 651-658, 2008.03.
25.     M. Noguchi, T. Kakuma, K. Tomiyasu, A. Yamada, K. Itoh, F. Konishi, S. Kumamoto, K. Shimizu, R. Kondo, K. Matsuoka , A randamized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms, Asian Journal of Andrology, 10, 5, 777-785, 2008.03.
26.     J. Liu, K. Shimizu, F. Konishi, K. Noda, S. Kumamoto, K. Kurashiki, R. Kondo, Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum , Food Chem. , 100, 1691-1696, 2007.06.
27.     J. Liu, K. Shimizu, F. Konishi, S. Kumamoto, R. Kondo, The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum, Bioorg. Med. Chem. , 15, 14, 4966-4972, 2007.03.
28.     J. Liu, K. Kurashiki, K. Shimizu,R. Kondo, Structure activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum, Bioorg. Med. Chem., 14, 24, 8654-60, 2006.12.
29.     J. Liu, K. Shimizu, R. Kondo, Ganoderic acid TR, a new lanostanoid with 5a-reductase inhibitory activity from the fruiting body of Ganodema lucidum., Natural Product Communications, 1, 5, 345-350, 2006.01.
30.     J. Liu, K. Kurashiki, K. Shimizu, R. Kondo, 5a-reductase inhibitory effects of triterpenoids isolated from Ganoderma lucidum., Biol. Pharm. Bull., 29, 392-395, 2006.01.