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北京大学 张永鹤教授

2016-11-16 15:46:26    来源:北京大学基础医学院    浏览:615次
  张永鹤教授,博士, 博士生导师,现任北京大学基础医学院药理学系副主任。兼任中国药理学会 副秘书长;中国药理学会神经精神药理专业委员会委员;制药工业药理学专业委员会委员;科技部863项目审评专家;科技部科技型中小企业技术创新基金评审专家;国家自然科学基金审评专家;教育部高校专家;《药理学通报》编委;《中国药理通讯》编委;北京市科学技术奖励评审专家。1983年毕业于延边大学(211大学)药学院获医学学士学位;1989年获沈阳药科大学天然药物化学专业理学硕士学位;1999年在韩国Chungbuk国立大学校获药理学博士学位。2000年2月至2001年3月受韩国教育部 BK 21项目组邀请,任退行性疾病的预防及治疗研究组特聘研究员。自2001年回国工作以来,先后主持了国家自然科学基金、“重大新药创制”科技重大专项“十一五”计划-候选药物项目、教育部基金、美国中华医学基金--人才专项基金、北京大学“十五”211和985工程项目等科研项目。自1983年以来,分别从事天然药物化学,神经药理和心血管药理的研究工作。在灵芝研究方面有一定的建树,在2016年国际灵芝大会上作《灵芝的中枢神经系统作用研究概况》专题报告。已在国内外杂志上发表论文60余篇,其中SCI收录论文30余篇。参编出版著作6本。

  研究领域:1. 在分子、细胞和整体动物水平研究与失眠、焦虑、忧郁等病症相关的受体、分子靶蛋白和功能基因;2. 研究细胞因子、神经内分泌功能和睡眠相关生物学,包括在动物模型和人体上研究神经内分泌应激反应和细胞因子诱导睡眠之间的相关性。3. 钙通道在睡眠及昼夜节律中调控作用研究;4. 失眠、焦虑和抑郁相关行为药理学动物模型建立及睡眠时相分析和脑电频谱特征研究;5. 安神及活血化瘀中药和天然药物药理学研究。


近年来发表的代表性学术论文(*为责任作者)

  1) Xin Zhao, Xiangyu Cui, Lien Wang, Yonghe Zhang*. Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: The TMN and VLPO as key elements in the pathway. Neuropharmacology. 2009, 56: 937-943. (IF:3.215)

  2) Lien Wang, Yanjing Bai, Xiaorong Shi, Xiangyu Cui, Suying Cui, Fan Zhang, Qingying Zhang, Yuying Zhao, Yonghe Zhang*. Spinosin, a C-glycoside flavonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system, Pharmacology Biochemistry and Behavior. 2008, 90(3): 399-403. (IF:2.355)

  3) Qingping Chu, Lien Wang, Xiangyu Cui, Hongzheng Fu, Zhibin Lin, Shuqian Lin, Yonghe Zhang*. Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanism. Pharmacol Biochem and Beh. 2007, 86 (4): 693-698. (IF:2.355)

  4) Xiangyu Cui, Xin Zhao, Qingping Chu, Baoqiong Chen, Yonghe Zhang*. Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test. J Neural Transm. 2007, 114 (2): 155-160. (IF:2.672)

  5) Yongri Jin, Xianghua Han, Yonghe Zhang, Jungjin Lee, Yong Lim, Tackjoong Kim, Hwansoo Yoo, Yeopyo Yun*. Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle. J Cell Biochem. 2009, 104: 1-14. (IF:3.381)

  6) Yongri Jin, Xianghua Han, Yonghe Zhang, Jungjin Lee, Yong Lim, Jinho Chung, Yeopyo Yun*. Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity. Atherosclerosis. 2007, 194 (1): 144-152. (IF: 4.287)

  7) Xin Zhao, Xiangyu Cui, Qingping Chu, Baoqiong Chen, Xiaomin Wang, Zhibin Lin, Xuejun Li, Baoshan Ku, Yonghe Zhang*. Potentiating effects of L-type Ca2+ channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system. J Neural Transm. 2006, 113 (10): 1395-1402. (IF: 2.938)

  8) Baoqiong Chen, Xiangyu Cui, Xin Zhao, Huishan Piao, Jinhwa Kim, Bumchun Lee, Hyeongbae Pyo, Yeopyo Yun, Yonghe Zhang*. Antioxidative and acute antiinflammatory effects of Torreya grandis Fort. Fitoterapia. 2006, 77 (4): 262-267. (IF:0.908)

  9) Xiangyu Cui, Jinhwa Kim, Xin Zhao, Baoqiong Chen, Bumchun Lee, Hyeongbae Pyo, Yeopyo Yun, Yonghe Zhang*. Antioxidative and acute antiinflammatory effects of Campsis grandiflora. J Ethnopharmacol. 2006, 103(2): 223-228. (IF:1.625)

  10) Ying Xu, Baoshan Ku*, Haiyan Yao, Yanhua Lin, Xing Ma, Yonghe Zhang, Xuejun Li. The effects of curcumin on depressive-like behaviors in mice. European Journal of Pharmacology, 2005, 518: 40- 46. (IF: 2.477)

  11) Ying Xu, Baoshan Ku*, Haiyan Yao, Yanhua Lin, Xing Ma, Yonghe Zhang, Xuejun Li. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem and Beh. 2005, 82: 200-206. (IF:1.97)

  12) Lianhua Fang, Yonghe Zhang*, Baoshan Ku. Fangchinoline inhibited the antinociceptive effect of morphine in mice. Phytomedicine. 2005, 12(3): 183-188. (IF:1.348)

  13) Xin Zhao, Xiangyu Cui, Baoqiong Chen, Qingoing Chu, Haiyan Yao, Baoshan Ku, Yonghe Zhang*. Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system. European Journal of Pharmacology. 2004, 506: 101-105. (IF: 2.432)

  14) Lianhua Fang, Yonghe Zhang*, Jingjie Ma, Guanhua Du, Baoshan Ku, Haiyan Yao, Yeopyo Yun, TJ Kim. Inhibitory effects of tetrandrine on the serum- and platelet derived growth factor-BB-induced proliferation of rat aortic smooth muscle cells through inhibition of cell cycle progression, DNA Synthesis, ERK1/2 Activation and c-fos Expression. Atherosclerosis 2004, 174(2): 215-223. (IF:3.796)

  15) Yonghe Zhang*, Lianhua Fang, Myungkoo Lee, Baoshan Ku. In vitro inhibitory effects of bergenin and norbergenin on bovine adrenal tyrosine hydroxylase. Phytother Res. 2003, 17: 967-969. (IF:1.43)

  16) Yonghe Zhang*, Lianhua Fang, Baoshan Ku. Fangchinoline inhibits rat aortic vascular smooth muscle cell proliferation and cell cycle progression through inhibition of ERK1/2 activation and c-fos expression. Biochem Pharmacol. 2003, 66(9): 1853-1860. (IF:4.006)