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台湾医药大学 高铭钦教授

2016-11-16 14:15:56    来源:2016国际灵芝大会    浏览:1379次
  1976年毕业于台湾国防医学院药学系并留任生化系助教,1983年负笈至美国路易斯安那州立大学,于1987年取得生化博士学位。回国后于国防医学院历任副教授、教授及生化所所长等职务,于2004年转服务于台中中国医药大学,历任医学院教授、附设医院分子医学中心副主任,并一手筹设癌症生物学研究所担任筹备主任,亦任生命科学院教授等职务,现任中国医药大学生技制药学院生物科技学系教授。并曾兼任「中药全球化联盟」(Consortium for Globalization of Chinese Medicine; CGCM)委员本校代表及两届联盟年会之Panelist。期间多次担任台湾行政院国家科学委员会生物处研究计划之复审委员,并曾担任生物技术开发中心、怡发科技公司及杏辉制药及杏国新药公司之学术顾问,更有多次筹办各项首届专业学术研讨会之创举(如第一届台湾中国医药大学暨亚洲大学联合生物科技研讨会等)。

  研究主题主要分为两大部分:(一)癌症基因治疗,发现四个基因药物即LT425, RIG1, EBNA1, MnSOD;(二)抗癌中草药研发,包括灵芝、四物汤等。发表论文80余篇,审编三本生物医学参考书籍,并获两项专利,受邀国内及国际演讲47次。过去获得的奖项包括国科会研究奖助、国际学术研讨会最佳论文奖(1992,1998)及多次获选为优良教师等。目前担任传统与替代药物期刊(Journal of Traditional and Complementary Medicine)的编辑委员。



期刊论文/Journal Paper

1、李宜臻(Yi-Jen Lee)、巫常诚(Chang-Cheng Wu)、李志玮(Jhy-Wei Li)、欧建志(Chien-Chih Ou)、许世忠(Shih-Chung Hsu)、曾秀学(Hsiu-Hsueh Tseng)、高铭钦(Ming-Ching Kao)、刘嘉耀(Jah-Yao Liu)*,A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers,Oncotarget,2016 Sep,():1-17,SCI

2、李家琳(Chia-Lin Lee)、李守伦(Lee, Shou-Lun)、陈朝荣(Chao-Jung Chen)、陈信君(HSIN-CHUN CHEN)、高铭钦(Ming-Ching Kao)、(Chuan-Hao Liu)、(Jau-Yang Chen)、(Yen-Ting Lai)、吴永昌(Yang-Chang Wu)*,Characterization of secondary metabolites from purple Ipomoea batatas leaves and their effects on glucose uptake,MOLECULES,2016 Jun,21():745,SCI

3、朱柏逢(Bo-Feng Chu)、林汉钦(Hang-Ching Lin)、黄涵郁(Han-Yu Huang)、黄信文(Xin-Wen Huang)、吴佩颖(Carol P. Wu)、高铭钦(Ming-Ching Kao)*,An ethanol extract of Poria cocos inhibits the proliferation of non-small cell lung cancer A549 cells via the mitochondria-mediated caspase activation pathway,Journal of Functional Foods,2016 Mar,23():614-627,SCI

4、李守伦(Lee, Shou-Lun)*、李显光(Hsien-Kuang Lee)、金亭佑(Ting-Yu Chin)、杜思洁(Ssu-Chieh Tu)、郭明勋(Ming-Hsun Kuo)、高铭钦(Ming-Ching Kao)*、吴永昌(Yang-Chang Wu)*,Inhibitory effects of purple sweet potato leaf extract on the proliferation and lipogenesis of the 3T3-L1 preadipocytes,AMERICAN JOURNAL OF CHINESE MEDICINE,2015 Aug,43(5):1-11,SCI

5、郭汉鹏(Han-Peng Kuo)、李宜臻(Yi-Jen Lee)、许志宇(Chih-Yu Hsu)、李守伦(Lee, Shou-Lun)、(Shih-Chung Hsu)、(Tzu-Chao Chuang)、(Jah-Yao Liu)、郭昭麟(Kuo Chao-Lin)、(Chi-Tang Ho)、高铭钦(Ming-Ching Kao)*,Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K/Akt pathway,Journal of Functional Foods,2015 Aug,17():600-609,SCI

6、李守伦(Lee, Shou-Lun)*、金亭佑(Ting-Yu Chin)、杜思洁(Ssu-Chieh Tu)、王禹杰(Yu-Jie Wang)、许雅婷(Ya-Ting Hsu)、高铭钦(Ming-Ching Kao)*、吴永昌(Yang-Chang Wu)*,Purple Sweet Potato Leaf Extract Induces Apoptosis and Reduces Inflammatory Adipokine Expression in 3T3-L1 Differentiated Adipocytes,Evidence-based Complementary and Alternative Medicine,2015 May,2015():,SCI

7、(Yin-Hua Shih)、(Kuo-Wei Chang)、(Cheng-Chia Yu)、高铭钦(Ming-Ching Kao)、陈远谦(Michael Yuan-Chien Chen)、(Tong-Hong Wang)、(Tzu-Yun Chi)、(Yi-Ling Chen)、谢宗明(Shieh Tzong-Ming)*,Hinokitiol suppressed pan-histone expression and cell growth in oral squamous cell carcinoma cells,Journal of Functional Foods,2015 Mar,15():452-463,SCI

8、郭汉鹏(Han-Peng Kuo)、(Shih-Chung Hsu)、(Chien-Chih Ou)、(Jhy-Wei Li)、(Hsiu-Hsueh Tseng)、(Tzu-Chao Chuang)、(Jah-Yao Liu)、(Shih-Jung Chen)、(Muh-Hwan Su)、(Yung-Chi Cheng)、高铭钦(Ming-Ching Kao)*,Ganoderma tsugae extract inhibits growth of HER2-overexpressing cancer cells via modulation of HER2/PI3K/Akt signaling pathway,Evidence-based Complementary and Alternative Medicine,2013 Apr,2013(2013):1-12,SCI

9、(Vinchi Wang)*、(Tzu-Chao Chuang)、高铭钦(Ming-Ching Kao)、(Din-E Shan)、(Bing-Wen Soong)、谢宗明(Shieh Tzong-Ming),Polymorphic Ala-allele carriers at residue 1170 of HER2 associated with Parkinson's disease,JOURNAL OF THE NEUROLOGICAL SCIENCES,2013 Jan,325(1):115-119,SCI

10、余养豪(Yang-Hao Yu)、郭汉鹏、谢蕙霞(Hui-Hsia Hsieh)、李志玮(Jhy-Wei Li)、徐武辉(Wu-Huei Hsu)、陈世荣(Shih-Jung Chen)、苏慕寰(Muh-Hwan Su)、刘淑惠(Shwu-Huey Liu)、郑永齐(Yung-Chi Cheng)、陈志毅(Chih-Yi Chen)*、高铭钦(Ming-Ching Kao)*,Ganoderma tsugae Induces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway,Evidence-based Complementary and Alternative Medicine,2012 Dec,2012(371286):1-13,SCI

11、郭汉鹏(Han-Peng Kuo)、庄子超(Tzu-Chao Chuang)、蔡士彰(Shih-Chang Tsai)、曾秀学(Hsiu-Hsueh Tseng)、许世忠(Shih-Chung Hsu)、陈昱璋(Yu-Chang Chen)、郭昭麟(Kuo Chao-Lin)、郭悦雄(Yueh-Hsiung Kuo)、刘嘉耀(Jah-Yao Liu)、高铭钦(Ming-Ching Kao)*,Berberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012 Sep,60(38):9649-9658,SCI

12、(Jang-Shiun Wang)、(Yeo-Loo Chang)、余养豪(Yang-Hao Yu)、陈志毅(Chih-Yi Chen)、高铭钦(Ming-Ching Kao)、(Tsai-Kun Li)、(Wan-Wan Lin)*,Cell type-specific effects of Adenosine 5'-triphosphate and pyrophosphate on the antitumor activity of doxorubicin,CANCER SCIENCE,2012 Aug,103(10):1811-1819,SCI

13、林嘉德(Chia-Der Lin)、蔡孟宏(Mang Hung Tsai)、林振文(Lin Cheng Wen)、何茂旺(Mao-Wang Ho)、王清源(Ching-Yuang Wang)、邹永恩(Yung-An Tsou)、高铭钦(Ming-Ching Kao)、蔡铭修(Ming-Hsui Tsai)*、赖志河(Chih-Ho Lai)*,Association of adenoid hyperplasia and bacterial biofilm formation in children with adenoiditis in Taiwan,EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY,2012 Apr,269(2):503-511,SCI

14、林慧怡(Lin Hui-Yi)、侯信丞(Shin-Chen Hou)、(Shi-Chen Chen)、高铭钦(Ming-Ching Kao)、余建志(Chien-Chih Yu)、(Shinji Funayama)、何其傥(Chi-Tang Ho)、魏宗德(Tzong-Der Way)*,(-)-Epigallocatechin gallate induces Fas/CD95-mediated apoptosis through inhibiting constitutive and IL-6-induced JAK/STAT3 signaling in head and neck squamous cell carcinoma cells,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2012 Feb,60(10):2480-2489,SCI

15、王文奇(Vin-Chi Wang)*、李志玮(Jhy-Wei Li)、(Jeng-Hung Suen)、庄子超(Tzu-Chao Chuang)、高铭钦(Ming-Ching Kao),Ile/Ile Homozygosity at Codon 655 of HER2 in Schwannoma,Acta Neurologica Taiwanica,2011 Dec,20(4):243-248,Other

16、叶明翰(Ming-Han Yeh)、蔡宗杰(Tzung-Chieh Tsai)、郭汉鹏(Han-Peng Kuo)、张乃文(Nai-Wen Chang)、李妙蓉(Miau-Rong Lee)、锺景光(Jing-Gung Chung)、蔡铭修(Ming-Hsui Tsai)、刘嘉耀(Jah-Yao Liu)、高铭钦(Ming-Ching Kao)*,Lentiviral short hairpin RNA screen of human kinases and phosphatases to identify potential biomarkers in oral squamous cancer cells,INTERNATIONAL JOURNAL OF ONCOLOGY,2011 Nov,39(5):1221-1231,SCI

17、(Ching-Yao Chang)、(Hong-Lin Chan)、林慧怡(Lin Hui-Yi)、魏宗德(Tzong-Der Way)、高铭钦(Ming-Ching Kao)、宋明璋(Ming-Zhang Song)、林应如(Ying-Ju Lin)、林振文(Lin Cheng Wen)*,Rhein Induces Apoptosis in Human Breast Cancer Cells,Evidence-based Complementary and Alternative Medicine,2011 Oct,2012(952504):1-8,SCI

18、郭汉鹏(Han-Peng Kuo)、庄子超(Tzu-Chao Chuang)、叶明翰(Ming-Han Yeh)、许世忠(Shih-Chung Hsu)、魏宗德(Tzong-Der Way)、陈柏源(Po-Yuan Chen)、王盛世(Shan-Shue Wang)、张永贤(Yung-Hsien Chang)、高铭钦(Ming-Ching Kao)*、刘嘉耀(Jah-Yao Liu)*,Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011 Aug,59(15):8216-8224,SCI

19、林嘉德(Chia-Der Lin)、高铭钦(Ming-Ching Kao)、蔡铭修(Ming-Hsui Tsai)、赖志河(Chih-Ho Lai)、魏一华(Wei I Hua)、蔡孟宏(Mang Hung Tsai)、汤智昕(Tang Chih-Hsin)、林振文(Lin Cheng Wen)、许权振(Chuan-Jen Hsu)、林清渊(Ching-Yuang Lin)*,Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway,LABORATORY INVESTIGATION,2011 Jul,91(7):1092-1106,SCI

20、张翔毓(Hsiang-Yu Chang)、高铭钦(Ming-Ching Kao)、魏宗德(Tzong-Der Way)、何其傥(Chi-Tang Ho)、傅锷(Earl Fu)*,Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011 May,59(10):5357-5363,SCI

21、林嘉德(Chia-Der Lin)、魏一华(Wei I Hua)、赖志河(Chih-Ho Lai)、夏德椿(Te-Chun Hsia)、高铭钦(Ming-Ching Kao)、蔡铭修(Ming-Hsui Tsai)、吴庆祥(Wu, Ching-Hsiang)、蔡孟宏(Mang Hung Tsai)*,Hyperbaric oxygen upregulates cochlear constitutive nitric oxide synthase,BMC NEUROSCIENCE,2011 Mar,12(21):1-10,SCI

22、张智翔(Chih-Hsiang Chang)、(Wei-Jou Cheng)、陈姗玗、高铭钦(Ming-Ching Kao)、姜中人(Chung-Jen Chiang)*、赵云鹏(Yun-Peng Chao)*,Engineering of Escherichia coli for Targeted Delivery of Transgenes to HER2/neu-Positive Tumor cells,BIOTECHNOLOGY AND BIOENGINEERING,2011 Feb,108(7):1662-1672,SCI

23、林嘉德(Chia-Der Lin)、魏一华(Wei I Hua)、蔡孟宏(Mang Hung Tsai)、高铭钦(Ming-Ching Kao)、赖志河(Chih-Ho Lai)、许权振(Chuan-Jen Hsu)、大岛猛史(Takeshi Oshima)、蔡铭修(Ming-Hsui Tsai)*,Changes in guinea pig cochlea after transient cochlear ischemia,NEUROREPORT,2010 Oct,21(15):968-975,SCI

24、王文奇(Vinchi Wang)*、(Shao-Yuan Chen)、庄子超(Tzu-Chao Chuang)、(Din-E Shan)、宋秉文(Bing-Wen Soong)、高铭钦(Ming-Ching Kao)*,Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease,CLINICAL BIOCHEMISTRY,2010 Aug,43(12):979-982,SCI

25、张乃文(Nai-Wen Chang)*、(Pei RJ)、曾宪彰(Hsien-Chang Tseng)、(Yeh KT)、詹淑秦(Hsu Chin Chan)、李妙蓉(Miau-Rong Lee)、林静茹(Chingju Lin)、谢文聪(Hsieh Wen-Tsong)、高铭钦(Ming-Ching Kao)、蔡铭修(Ming-Hsui Tsai)、林锦芬(Lin, Chin-Fen)*,Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis 1-oxide.,CHEMICO-BIOLOGICAL INTERACTIONS,2010 Jan,183():231-237,SCI

26、郑杰文、(谢博铨)、林英超、(Yi-Jen Chen)、(Yu-Huei Lin)、(Daih-Huang Kuo)、(Jah-Yao Liu)、高铭钦(Ming-Ching Kao)*、(Jung-Yie Kao)*、魏宗德(Tzong-Der Way)*,Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein,Is Suppressed by (-)-Epigallocatechin-3-gallate via Blocking of γ-Interferon-Induced JAK-PKC-δ-STAT1 Signaling in Human Oral Cancer Cells,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2010 Jan,58(2):887-894,SCI

27、(Shih-Chung Hsu)、(Chien-Chih Ou)、(Tzu-Chao Chuang)*、(Jhy-Wei Li)、(Yi-Jen Lee)、(Jah-Yao Liu)、(Chin-Shiang Chen)、(Song-Chow Lin)*、高铭钦(Ming-Ching Kao)*,Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: in vitro and in vivo,CANCER LETTERS,2009 Feb,281(1):108-116,SCI

28、刘嘉耀(Liu JY)、庄子超(Chuang TC)*、魏宗德(Tzong-Der Way)、蔡宗杰(Tsai TC)、胡志麟(Hu CL)、刘光耀(Liu GY)、王盛世(Wang SS)、锺景光(Jing-Gung Chung)、高铭钦(Ming-Ching Kao)*,The N-terminal domain of EBNA1 acts as a suppressor of the HER2/neu oncogene,CANCER LETTERS,2009 Jan,273(2):273-280,SCI

29、王文奇(Wang V)、庄子超(Chuang TC)、宋秉文(Soong BW)、(Shan DE)*、高铭钦(Ming-Ching Kao)*,Octarepeat changes of prion protein in Parkinson's disease,PARKINSONISM & RELATED DISORDERS,2009 Jan,15(1):53-58,SCI

30、陈荣洲(Jung-Chou Chen)、吕孔文(KUNG-WEN LU)、蔡明俐(Ming-Li Tsai)、(Shu-Chun Hsu)、郭昭麟(Kuo Chao-Lin)、杨家欣(Yang Jai-Sing)、夏德椿(Te-Chun Hsia)、(Chun-Shu Yu)、(Su-Tze Chou)、高铭钦(Ming-Ching Kao)、锺景光(Jing-Gung Chung)*、(W. Gibson Wood),Gypenosides induced G0G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells,ORAL ONCOLOGY,2009 ,45(0):273-283,SCI

31、林振文(Lin Cheng Wen)*、(Chieh-Wen Cheng)、杨翠青(Tsuey-Ching Yang)、(Shih-Wein Li)、(Mei-Hsiu Cheng)、万磊(Lei Wan)、林应如(Ying-Ju Lin)、赖志河(Chih-Ho Lai)、林维勇(Wei-Yong Lin)、高铭钦(Ming-Ching Kao)*,Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42,VIRUS RESEARCH,2008 Nov,137(1):49-55,SCI

32、(Shih-Chung Hsu)、(Chien-Chih Ou)、(Jhy-Wei Li)、(Tzu-Chao Chuang)*、(Han-Pon Kuo)、(Jah-Yao Liu)、(Chin-Shiang Chen)、(Song-Chow Lin)、(Ching-Hua Su)、高铭钦(Ming-Ching Kao)*,Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G2/M cell cycle arrest,JOURNAL OF ETHNOPHARMACOLOGY,2008 Oct,120(3):394-401,SCI

33、廖雅芳(Liao YF)、洪慧芝(Hung HC)、(Hsu PC)、高铭钦(Ming-Ching Kao)、(Hour TC)、蔡嘉哲(Tsay GJ)、刘光耀(Liu GY)*,Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB,LEUKEMIA RESEARCH,2008 Jul,32(7):1124-1140,SCI

34、李正常(Jang-Chang Lee)、蔡志彦(Chih-Yen Tsai)、高振益(Jung-Yie Kao)、高铭钦(Ming-Ching Kao)、蔡士彰、张志祥(Chih-Shiang Chang)、黄丽娇(Li-Jiau Huang)、郭盛助(Sheng-Chu Kuo)、林仁混、魏宗德(Tzong-Der Way)*,Geraniin-Mediated Apoptosis by Cleavage of Focal Adhesion Kinase through Up-Regulation of Fas ligand Expression in Human Melanoma Cells,MOLECULAR NUTRITION & FOOD RESEARCH,2008 Jun,(52):655-663,SCI

35、廖雅芬(Liao YF)、洪慧芝(Hung HC)、(Hour TC)、(Hsu PC)、高铭钦(Ming-Ching Kao)、(Tsay GJ)、刘光耀(Liu GY)*,Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells,LIFE SCIENCES,2008 Feb,82(7-8):367-375,SCI

36、白礼源(Li-Yuan Bai)、邱昌芳(Chang-Fang Chiu)*、林振文(Lin Cheng Wen)、许南荣(Nan-Yung Hsu)、林娇玲(Chiao-Lin Lin)、罗文吉(Wen-Jyi Lo)、高铭钦(Ming-Ching Kao)*,Differential expression of Sonic hedgehog and Gli1 in hematological malignancies,LEUKEMIA,2008 Jan,22(1):226-228,SCI

37、欧建志(Chien-Chih Ou)、许世忠(Shih-Chung Hsu)、谢胤辉(Yin-Hui Hsieh)、邹宛玲(Won-Ling Tzou)、庄子超(Tzu-Chao Chuang)、刘嘉耀(Jha-Yao Liu)*、高铭钦(Ming-Ching Kao)*,Downregulation of HER2 by Interferon-gamma-Induced RIG1 Involves the PI3K/Akt Pathway in Ovarian Cancer Cells,CARCINOGENESIS,2008 Jan,29(2):299-306,SCI

38、(Tzu-Chao Chuang)*、(Jha-Yao Liu)、(Chi-Tsai Lin)、(Ya-Ting Tang)、(Ming-Han Yeh)、(Su-Chien Chang)、(Jhy-Wei Li)、高铭钦(Ming-Ching Kao)*,Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy,FEBS LETTERS,2007 Sep,581(23):4443-4449,SCI

39、(Chin-Chung Lin)、杨家欣(Yang Jai-Sing)、(Jin-Tang Chen)、(Shang Fan)、(Hung-Pin Wang)、(Jiun-Long Yang)、(Chi-Cheng Lu)、高铭钦(Ming-Ching Kao)、(An-Cheng Chang)、(Hsu-Feng Lu)、锺景光*,Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway,ANTICANCER RESEARCH,2007 Aug,27(27):3371-3378,SCI

40、汤智昕(Tang Chih-Hsin)、卢大宇(Lu, Dah-Yuu)、杨荣森(Yang RS)、蔡辉彦(Huei-Yann Tsai)、高铭钦(Ming-Ching Kao)、符文美(Fu Wen-Mei)*、陈玉芳*,Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, PI3K, Akt, NF-kB, and p300 pathway in microglia,JOURNAL OF IMMUNOLOGY,2007 Jul,179(2):1292-1302,SCI

41、(Lu H. F.)、(Hsueh S. C.)、(Ho Y. T.,)、高铭钦(Ming-Ching Kao)、杨家欣、(Chiu T. T.,)、(Huang S. Y.,)、(Lin C. C.)、锺景光*,ROS Mediates Baicalin-induced Apoptosis in Human Promyelocytic Leukemia HL-60 Cells through the Expression of the GADD153 and Mitochondria-dependent Pathway.,ANTICANCER RESEARCH,2007 Mar,27(27):117-126,SCI

42、(Liu GY)、(Liao YF)、(Hsu PC)、(Chang WH)、(Hsieh MC)、(Lin CY)、(Hour TC)、高铭钦(Ming-Ching Kao)、(Tsay GJ)、(Hung HC)*,Antizyme, a natural ornithine decarboxylase inhibitor, induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases' cascade,APOPTOSIS,2006 Oct,10(11):1773-1788,SCI

43、(Hsu PC)、(Hour TC)、(Liao YF)、(Hung YC)、(Liu CC)、(Chang WH)、高铭钦(Ming-Ching Kao)、(Tsay GJ)、(Hung HC)、(Liu GY)*,Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2,APOPTOSIS,2006 Mar,3(11):389-399,SCI

44、(Law SL)、(Chuang TC)、高铭钦(Ming-Ching Kao)、(Lin YS)、(Huang KJ),Gene Transfer Mediated by Sphingosine/Dioleoylphosphatidylethanolamine Liposomes in the Presence of Poloxamer 188,DRUG DELIVERY,2006 Jan,13(1):61-67,SCI

45、(Huang CC)、(Hsu PC)、(Hung YC)、(Liao YF)、(Liu CC)、(Hour CT)、高铭钦(Ming-Ching Kao)、(Tsay GJ)、(Hung HC)、(Liu GY)*,Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production,APOPTOSIS,2005 Aug,4(10):895-907,SCI

46、(Wang V)、(Chuang TC)、(Hsu YD)、(Chou WY)、高铭钦(Ming-Ching Kao)*,Nitric oxide induces prion protein via MEK and p38 MAPK signaling,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005 Jul,1(333):95-100,SCI

47、(Li JW)、(Chuang TC)、(Yang AH)、(Hsu CK)、高铭钦(Ming-Ching Kao)*,Clinicopathological relevance of HER2/neu and a related gene-protein cubic regression correlation in colorectal adenocarcinomas in Taiwan,INTERNATIONAL JOURNAL OF ONCOLOGY,2005 Apr,4(26):933-943,SCI

48、(Lin SH)*、(Hsu YD)、(Cheng NL)、高铭钦(Ming-Ching Kao),Skeletal muscle dihydropyridine-sensitive calcium channel (CACNA1S) gene mutations in chinese patients with hypokalemic periodic paralysis,AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2005 Feb,2(329):66-70,SCI

49、魏宗德、高铭钦(Ming-Ching Kao)、(Lin JK*)*,Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells,FEBS LETTERS,2005 Jan,579(1):145-152,SCI

50、魏宗德、(Lee HH)、高铭钦(Ming-Ching Kao)、(Lin JK*)*,Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression.,EUROPEAN JOURNAL OF CANCER,2004 Sep,40(14):2165-2174,SCI

51、魏宗德(Tzong-Der Way)、高铭钦(Ming-Ching Kao)、林仁混(Lin JK)*,Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway,JOURNAL OF BIOLOGICAL CHEMISTRY,2004 Feb,6(279):4479-4489,SCI

52、(Chuang TC)、(Lee YJ)、(Liu JY)、(Lin YS)、(Lee JW)、(Wang V)、(Law SL)、高铭钦(Ming-Ching Kao)*,EBNA1 may prolong G2/M phase and sensitize HER2/neu-overexpressing ovarian cancer cells to both topoisomerase II-targeting and paclitaxel drugs,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2003 Aug,307(3):653-659,SCI

53、(Chuang TC)、(Lee YJ)、(Liu JY)、(Lin YS)、(Li JW)、(Wang V)、(Law SL)、高铭钦(Ming-Ching Kao)*,EBNA1 may prolong G(2)/M phase and sensitize HER2/neu-overexpressing ovarian cancer cells to both topoisomerase II-targeting and paclitaxel drugs,BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2003 Aug,3(307):653-659,SCI

54、(Cheng NL)、高铭钦(Ming-Ching Kao)、(Hsu YD)、(Lin SH)*,Two novel thiazide-sensitive Na-Cl cotransporter mutations in a Chinese patient with Giteman's Syndrome presenting as hypokalemic paralysis,NEPHROLOGY DIALYSIS TRANSPLANTATION,2003 May,5(18):1005-1008,SCI

55、(Chuang TC)、(Way TD)、(Lin YS)、(Lee YC)、(Law SL)、高铭钦(Ming-Ching Kao)*,The Epstein-Barr virus nuclear antigen-1 may act as a transforming suppressor of the HER2/neu oncogene,FEBS LETTERS,2002 Dec,1-2(532):135-142,SCI

56、(Chuang TC)、魏宗德、(Lin YS)、(Lee YC)、(Law SL)、高铭钦(Ming-Ching Kao)*,The Epstein–Barr virus nuclear antigen-1 may act as a transforming suppressor of the HER2/neu oncogene,FEBS LETTERS,2002 Nov,(532):135-142,SCI

57、(Chuang TC)、(Yu YH)、(Lin YS)、(Wang SS)、高铭钦(Ming-Ching Kao)*,The N-terminal domain of SV40 large T antigen represses the HER2/neu-mediated transformation and metastatic potential in breast cancers,FEBS LETTERS,2002 Jan,1-3(511):46-50,SCI

58、张淑缄(Chang SC)、高铭钦(Ming-Ching Kao)、傅明慈(Ming-Tsze Fu)、林棋财(Chi-Tsai Lin)*,Modulation of NO and cytokines in microglial cells by Cu/Zn-SOD,FREE RADICAL BIOLOGY AND MEDICINE,2001 Jul,9(31):1084-1089,SCI

59、(Shyu WC)*、高铭钦(Ming-Ching Kao)、(Chou WY)、(Hsu YD)、(Song BW),Creutzfeld-Jakob disease - Heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study,JOURNAL OF NEUROLOGY,2000 Dec,12(247):929-934,SCI

60、(Shyu WC)*、高铭钦(Ming-Ching Kao)、(Chou WY)、(Hsu YD)、(Song BW),Heat shock modulates prion protein expression in human NT-2 cells,NEUROREPORT,2000 Mar,4(11):771-774,SCI

61、(Lin CT)*、(Kuo TZ)、(Shaw JF)、高铭钦(Ming-Ching Kao),Characterization of the dimer-monomer equilibrium of the Papaya Cu/Zn SOD and its equilibrium shift by a single amino acid mutation,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,1999 Jul,7(47):2944-2949,SCI

62、(Hu KY)、(Wuu JA)、高铭钦(Ming-Ching Kao)*、(Liu YT)、(Pai SH),Isolation and characterization of a newly identified restriction endonuclease from a local Streptomyces sp. in Taiwan,APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,1998 Sep,2-3(73):231-241,SCI

63、高铭钦(Ming-Ching Kao)*、(Liu KY)、(Chuang TC)、(Lin YS)、(Wuu JA)、(Law SL),The N-terminal 178-amino-acid domain only of the SV40 large T antigen act as a transforming suppressor of the HER2/neu oncogene,ONCOGENE,1998 Jun,4(16):547-554,SCI

64、高铭钦(Ming-Ching Kao)*、(Law SL)、(Chuang TC)、(Lin YS),In vitro gene delivery in mammalian cells via a new cationic liposome formulation,ONCOLOGY REPORTS,1998 May,3(5):625-629,SCI